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Search on : COMPLEXO DE PROTEINAS ASSOCIADAS DISTROFINA/IM [Subject descriptor]
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Id:17690
Author:Rambukkana, Anura
Title:Mycobacterium leprae-induced demyelination: a model for early nerve degeneration ..-
Source:s.l; s.n; 2004. 8 p. ilus, tab.
Abstract:The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration. (AU).
Descriptors:Axônios/IM/PA/UL
Doenças Auto-Imunes Desmielinizantes do Sistema Nervoso Central/ET/*IM/MI/PP
Distroglicanas/*IM
Complexo de Proteínas Associadas Distrofina/IM
Hanseníase/CO/*IM
Mycobacterium leprae/*IM
Bainha de Mielina/*IM
Células de Schwann/*IM/MI/PA
Limits:HUMANO
ANIMAL
CAMUNDONGOS
SUPPORT, U.S. GOV'T, NON-P.H.S.
SUPPORT, U.S. GOV'T, P.H.S.
Location:BR191.1; 09364/S


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